The motorcycle ignited after impact, and the two drivers, a male in his late 40s and a female in her late 50s were transferred by EMS to the Fort Duncan Regional Medical Center and were in stable but serious condition, said Fire Chief Manuel Mello.
The drivers suffered injuries ranging from scrapes and bruises to fractured bones and burns, and were both air lifted to San Antonio for further medical treatment.
The Eagle Pass Police Department is investigating the crash.