Flores was ousted by Democratic Party Candidate Roland Gutierrez.
Gutierrez received 156,741 votes or 49.9% while Flores had 146,395 or 46.6 %.
Senator Flores released the following statement regarding the election results.
“Yesterday's election results were not what we had hoped for, but this campaign has come to an end. I send my heartfelt thanks to the people of the District. I appreciate the opportunity to serve as their State Senator for the 86th Session. I want to thank the Lt. Governor and my colleagues in the Texas Senate for their support as we accomplished a great many things for the people of Texas and this District. And most of all, I thank my family for their support and understanding throughout this time in public office,” said Flores. “Together we made history, winning this seat in 2018. We again achieved historic and unprecedented results but fell short of reelection. Electorally, we made gains in every county, and for that I thank each one of you. I am encouraged by the fact that we held Mr. Gutierrez to under 50%. The results also show that we flipped Brewster, Frio, Reeves, and Val Verde counties from Blue to Red, and made double-digit gains in Maverick and Zavala. South and west Texas continue to trend Republican. This district is diverse and unique. While I have lived much of my life here, I learned each day from the people, and they have made me a better man.”
"I will complete my term in January, but my service to the people of south and west Texas will continue," Flores concluded.