Doctors face a delicate balance in broaching the idea of yet another medical procedure when families have been hit with a horrible diagnosis and difficult treatment plan. The tissue-removing surgeries are typically done while a child is being sedated for another reason.
    "We try to be thoughtful about the fact that their main focus and ours is on the survival of the child," said Dr. Erin Rowell, a surgeon at Chicago's Lurie Children's Hospital, where Talia is being treated.
    Yet, Rowell added, many families are open to hearing about saving their child's fertility.
    "That often is the one piece of information that gives them a glimmer of hope - that we believe that their children will live long enough to grow into adulthood and have their own family," she said.
    A baby boy in Belgium makes scientists think they're on the right track. He was born to a woman who at age 13 had ovarian tissue removed before undergoing harsh treatment for sickle cell anemia. Doctors believe she had signs of puberty when the tissue was frozen, according to a recent medical journal report. Ten years later the tissue was thawed, and portions were grafted onto her remaining ovary. She gave birth last November after a normal pregnancy.
    She is the youngest person to date to have had success. Although her eggs were likely more mature than those of pre-puberty girls, the results are "super exciting," said Dr. Jill Ginsberg of Children's Hospital of Philadelphia, a pioneer in the field.
    The irony of cancer treatment is that it can save lives while destroying the chance to create a new life. Chemotherapy works by killing rapidly dividing cells. These include malignant cells but also hair follicles, digestive tract cells, and sperm and eggs. Radiation can also damage these cells.
    Dr. John Lantos, bioethics chief at Children's Mercy Hospital in Kansas City, Missouri, says offering children the experimental fertility-preserving procedures poses no ethical problems "as long as there's informed consent and a desire to do it."
    Federal guidelines say there should be minimal risk to children involved in research, and risks need to be weighed against potential benefits, he said.
    "Kids themselves when they grow up would likely appreciate having that (fertility) option," he said.
    After the tissue is removed, some is stored in liquid nitrogen for the patient's future use and some is sent to a central research lab at Northwestern University in Chicago, where scientists are studying ways to make it work.
    Since 2008, the Philadelphia hospital has saved tissue for about 40 girls aged 3 and up and 50 boys - the youngest was 3 months. A few have since died but most still have tissue on ice, waiting for science and adulthood.
    Deaths from cancer are uncommon in children; about 80 percent survive, "so we have the odds in our favor," Ginsberg said.
    At age 10, Michael Richert recently finished treatment for a brain tumor. The North Brunswick, New Jersey, boy had testes tissue removed earlier this year at the Philadelphia hospital after a stem cell transplant, before starting chemotherapy. He comes from a large extended family, and from his hospital bed, mused about playing a Legos video game with a future son "like me and my dad did."
    His mom, Aileen Richert, says consenting to the procedure was tough.
    "But then I was thinking, years from now, if my son gets married and wants to have children, what if I told him I'd had this option and I didn't do it for him?" she said.
    Parents help doctors present the details, depending on the child's maturity, Ginsberg said. "Some kids want to know every detail. Others are like `I've heard enough.'"
    When 8-year-old Hannah McStay of Mantua, New Jersey, was diagnosed with leukemia, the offer of ovary-freezing forced her mom, Rachel, to have a very grown-up conversation with her.
    Now 11, with her leukemia in remission, Hannah says the potential chance for fertility is "a miracle."